Cetirizine, a human metabolite of hydroxyzine, is a potent and selective antagonist of peripheral H1-receptors. In vitro receptor binding studies have shown no measurable affinity for other than H1-receptors. Undesirable effects are described according to MedDRA System Organ Class and by estimated frequency based on post-marketing experience. Elderly: Following a single 10 mg oral dose, half-life increased by about 50 % and clearance decreased by 40 % in 16 elderly subjects compared to the normal subjects. The decrease in cetirizine clearance in these elderly volunteers appeared to be related to their decreased renal function. In addition to the adverse reactions reported during clinical studies and listed above, the following undesirable effects have been reported in post-marketing experience.

Galpharm Cetirizine Hayfever and Allergy Relief Tablets

These tablets should always be kept out of sight and reach of children. Will taking Galpharm Cetirizine and Hydrochloride tablets make you drowsy? The distribution of pharmacokinetic parameters such as peak plasma concentration (Cmax) and area under curve (AUC), is unimodal in human volunteers. The extent of absorption of cetirizine is not reduced with food, although the rate of absorption is decreased. The extent of bioavailability is similar when cetirizine is given as solutions, capsules or tablets. Adverse events reported after an intake of at least 5 times the recommended daily dose are: confusion, diarrhoea, dizziness, fatigue, headache, malaise, mydriasis, pruritus, restlessness, sedation, somnolence, stupor, tachycardia, tremor, and urinary retention. Symptoms observed after an overdose of cetirizine are mainly associated with CNS effects or with effects that could suggest an anticholinergic effect.

Brand

Due to the pharmacokinetic, pharmacodynamic and tolerance profile of cetirizine, no interactions are expected with this antihistamine. Actually, neither pharmacodynamic nor significant pharmacokinetic interaction was reported in drugdrug interactions studies performed, notably with pseudoephedrine or theophylline (400 mg/day). Giving you relief for up to 24 hours, Galpharm Hay fever and Allergy Relief tablets help to soothe common hay fever symptoms: such as itchy or watery eyes, sneezing and a runny nose. These long-lasting hay fever tablets also stop symptoms from other allergies e.g. pet, house dust mite and mould spore allergies. What is an allergy? Like all medication, Galpharm Hay fever and Allergy Relief Cetirizine Hydrochloride tablets may cause mild side effects in some people, such as drowsiness. See the enclosed leaflet for the common side effects of Galpharm cetirizine tablets.

Hayfever Tablets For Dogs | Piriton | Antihistamines Hayfever Tablets For Dogs | Piriton | Antihistamines

Used for the relief of hay fever and allergies, Galpharm cetirizine hydrochloride tablets help to prevent symptoms for up to 24 hours. Galpharm antihistamine tablets do not cause drowsiness in most people. However, as with other antihistamines, rare cases of drowsiness have been reported. If affected do not drive or operate machinery. As with all antihistamines, you should avoid excessive alcohol consumption when taking this medicine. Can you take Galpharm Cetirizine and Hydrochloride tablets when pregnant or breastfeeding?Although statistically more common than under placebo, somnolence was mild to moderate in the majority of cases. Objective tests as demonstrated by other studies have demonstrated that usual daily activities are unaffected at the recommended daily dose in healthy young volunteers. Clinical studies have shown that cetirizine at the recommended dosage has minor undesirable effects on the CNS, including somnolence, fatigue, dizziness and headache. In some cases, paradoxical CNS stimulation has been reported. Patients on hemodialysis (creatinine clearance less than 7 ml/min) given a single oral 10 mg dose of cetirizine had a 3-fold increase in half-life and a 70 % decrease in clearance compared to normals. In addition to its anti-H1 effect, cetirizine was shown to display anti-allergic activities: at a dose of 10 mg once or twice daily, it inhibits the late phase recruitment of eosinophils, in the skin and conjunctiva of atopic subjects submitted to allergen challenge. Cetirizine is excreted in human milk at concentrations representing 25% to 90% of those measured in plasma, depending on sampling time after administration. Therefore, caution should be exercised when prescribing cetirizine to lactating women.

Galpharm Treathay Hayfever Relief Fexofenadine, 30 Count Galpharm Treathay Hayfever Relief Fexofenadine, 30 Count

Cetirizine is indicated for the relief of nasal and ocular symptoms of seasonal and perennial allergic rhinitis. Caution should be taken in patients with predisposition factors of urinary retention (e.g. spinal cord lesion, prostatic hyperplasia) as cetirizine may increase the risk of urinary retention. GALPHARM HAYFEVER AND ALLERGY RELIEF, WILKO HAYFEVER & ALLERGY RELIEF, NUMARK HAYFEVER AND ALLERGY RELIEF, SPAR HAYFEVER & ALLERGY RELIEF 10 MG TABLETS, BECOALLERGY 10 MG TABLETS, ASDA HAYFEVER & ALLERGY RELIEF, SAINSBURYS HEALTHCARE HAYFEVER AND ALLERGY - summary of medicine characteristicsCetirizine does not undergo extensive first pass metabolism. About two third of the dose are excreted unchanged in urine. The terminal half-life is approximately 10 hours. Patients with moderate to severe renal impairment: there are no data to document the efficacy/safety ratio in patients with renal impairment. Since cetirizine is mainly excreted via renal route (see section 5.2), in cases no alternative treatment can be used, the dosing intervals must be individualized according to renal function. Refer to the following table and adjust the dose as indicated. To use this dosing table, an estimate of the patient’s cre­atinine clearance (CLcr) in ml/min is needed. The CLcr (ml/min) may be estimated from serum creatinine (mg/dl) determination using the following formula: Children, infants and toddlers: The half-life of cetirizine was about 6 hours in children of 6–12 years and 5 hours in children 2–6 years. In infants and toddlers aged 6 to 24 months, it is reduced to 3.1 hours Do not exceed the stated dose Do not use if you are pregnant or breastfeeding. If symptoms persist consult your doctor. Keep out of the sight and reach of children The apparent volume of distribution is 0.50 l/kg. Plasma protein binding of cetirizine is 93 ± 0.3%.